Anesthesia of mandibular teeth in adults by the infiltration method is best achieved by which anesthetic?

The use of Articaine 4% with epinephrine 1:100,000 is optimal for achieving anesthesia of the mandibular teeth through the infiltration method due to several key factors. Articaine is unique among local anesthetics because it has a higher lipid solubility and a smaller molecular weight compared to other common anesthetics, which enhances its ability to penetrate bone and soft tissue. This characteristic makes it particularly effective in anesthetizing the mandibular region, which often poses challenges due to the dense nature of mandibular bone.

Additionally, the 4% concentration of Articaine provides a greater density of anesthetic agent at the site of infiltration, contributing to a more profound and quicker onset of anesthesia. The presence of epinephrine at a dilution of 1:100,000 serves to prolong the duration of anesthesia and minimize bleeding in the surgical field, further enhancing its efficacy in dental procedures.

Other anesthetics presented in the options, while effective, do not possess the same penetrating capability or concentration profile that Articaine does, making them less effective choices for this specific application in adults.